Question 1 of 60

A 34-year-old man presents with 2 weeks of progressive periorbital and lower-extremity edema and frothy urine. Serum albumin is 2.4 g/dL and total cholesterol is 320 mg/dL. Urinalysis shows 4+ protein and oval fat bodies. Which of the following tests best quantifies the degree of proteinuria to confirm nephrotic-range disease?

• A.Spot urine protein-to-creatinine ratio (or 24-hour urine protein)
• B.Serum blood urea nitrogen and creatinine
• C.Urine microscopy for red cell casts
• D.Serum complement (C3 and C4) levels
• E.Renal ultrasound with Doppler